AMC-092: A multicenter observational and feasibility study of excision of superficially invasive squamous cell carcinoma (SISCCA) of the anal canal and perianus in HIV-infected persons


Anal SISCCA is a small anal cancer that has not spread deeply into the tissues in and around the anus or anal sphincter (muscle that closes the anus). The typical treatment for SISCCA is surgical removal with a large margin of normal tissue and/or chemotherapy with radiation therapy. If caught early, anal cancer is often cured, but side effects from the treatments can be severe, and some can last for several years.

Other studies suggest that local surgery to remove SISCCA without a large margin of normal tissue may be a safe treatment alternative. The goal of this study is to test whether local surgical removal to treat SISCCA combined with treating any precancerous lesions that may be present could be an alternative to a bigger surgery, or to radiation and chemotherapy, and whether this treatment is well tolerated.

Study eligibility & contact

For details about the eligibility criteria please contact Arezou Sadighi Akha:
Tel: 415-353-9042
Email: [email protected]